The CPR Mask with one-way valve is used during Respiratory and Cardiac Emergencies as a physical barrier device when administering rescue breaths to a person. The one-way valve prevents bodily fluids and airborne pathogens from reaching the rescuer. The medical-grade thermoplastic mask has a soft inflated cuff for a leakproof seal and adds to the patient's comfort as well as an elastic head strap allowing the rescuer to secure the mask to the patient's face. Also included, is an oxygen inlet for optional supplemental oxygen.